A new Cochrane review on dietary salt interventions was published last week by Graudal et. al (1), an update to a 2003 review. The meta-analyses examined the effects of randomized interventions with high or low dietary salt on blood pressure (BP), hormones and lipids. The trials included consisted of subjects with normal or elevated BP, and sodium intake estimated via 24 hour sodium excretion. In total, 167 studies were included that compared dietary sodium intakes <120 mmol with >150 mmol. In studies on subjects with elevated BP, the median trial duration was 28 days,and the average 24 hour sodium excretion in the trials were 71 mmol in the low-salt intake groups and 196 mmol in the high salt groups. In studies on subjects with normal BP, the median trial duration was 7 days, and the average 24 hour sodium excretion in the trials were 50 mmol in the low-salt intake groups and 201 mmol in the high salt groups.
Outcomes were systolic (SBP), diastolic (DSP), and mean BP (MBP), renin, aldosterone, adrenaline, noradrenaline, triglyceride, cholesterol, LDL, and HDL. The results were also analyzed by race.