Category Archives: Insulin Resistance

Dietary sulforaphane reduces oxidative stress in diabetes

Type 2 diabetes is characterized by increased oxidative stress, which may result in vascular pathologies (Bekyarova, Ivanova, and Madjova, 2007). Certain dietary phytochemicals may ameliorate oxidative stress and restore a more normal metabolic milieu. As reviewed by Angeloni, Leoncini, Malaguti, Angelini, Hrelia, and Hrelia (2009), one such phytochemical found in cruciferous vegetables such as broccoli sprouts, sulforaphane (SFN), induces phase-II enzymes and increases endogenous antioxidant activity, Read more [...]

Ageing per se increases susceptibility to lipid induced insulin resistance in rats

I am constantly on the lookout for studies on how biochemical mechanisms shift with age, the significance of these changes and how nutrition and lifestyle interact with them to potentially affect health.  Ageing itself is clearly an immensely complex process, and teasing out changes caused from ageing itself rather than known variables that effect health is difficult. A recent paper by Francine Einstein et al. (1) examined how age influences susceptibility to free fatty acid (FFA) induced insulin Read more [...]

Insulin resistance as a protective mechanism, a paradigm shift?

Oxidative stress has been implicated implicated in insulin resistance, and a new study by Hoehn et al. (1) adds some convincing evidence that one specific radical, superoxide generated in the mitochondria, may be a unifying cause.  But the findings suggest that we may need to reconsider how we treat it. The authors begin by suggesting that the failure of the recent ACCORD trial that found an increase in mortality when trying to lower glycated hemoglobin with drugs and/or insulin in diabetics Read more [...]