Category Archives: miRNA

PLIN4 allele-specific influence on microRNA binding has subtle effects on obesity phenotypes

Kris Richardson et al. (including Larry Parnell and Jose Ordovas who are on Twitter) give a fascinating example of a gene-diet interaction yesterday in PLoS One (press release); the variant on a mRNA region allows microRNA to bind (miR; short chain non-coding RNA) that is of relevance to nutrition. The perilipins (PLIN1 - 5) are proteins coat the surfaces of lipid droplets in adipocytes where triacylglycerols are stored.  PLIN4 facilitates free fatty acid uptake, whereas PLIN1 and other perilipins Read more [...]