Generational increases in stochastic epigenetic variability to sustained methyl donor supplementation in mice
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This recent paper in PLoS Genetics by Cheryl C. Y. Li and colleagues (from a group that did earlier work with the agouti mouse model) was really fascinating- they looked at changes in methylation variability in response to dietary supplementation of methyl donors across multiple generations of mice. Some very novel and important findings (summary at the bottom).
This time, they focused on CpG islands in the whole genome of (C57BL/6) mice fed methyl donors (similar to agouti studies: choline, betaine, Read more [...]