Author Archives: Colby Vorland

Weekend Update

Vivid food ads implant false memories of consuming the product Ads Implant False Memories | Wired Science | Wired.com The Harvard epidemiological study that was all over the news this week (potatoes) on some specific foods and lifestyles that associate with weight gain (big names in nutritional epidemiology): http://www.nejm.org/doi/full/10.1056/NEJMoa1014296 Nice post by Caitlin Mason, the first author in the recent study on vitamin D and weight loss: Does weight loss influence vitamin Read more [...]

Weekend Update

Super busy and a super late (and short) links from 2 weeks ago: More reasons to ban front-of-package labeling- our perceptions seems to effect ghrelin levels You Are What You (Think) You Eat | Miller-McCune More evidence that dehydration and electrolyte imbalances are not the causes of cramps during exercise: Increased running speed and previous cramps rather than dehydration or serum sodium changes predict exercise-associated muscle cramping: a prospective cohort study in 210 Ironman Read more [...]

Weekend Update

USDA to replace MyPyramid with a dinner plate- NYTimes Prenatal Vitamins, One-carbon Metabolism Gene Variants, and Risk for Autism CVD is a bit more complicated than the traditional biomarkers: Study: Boosting Good Cholesterol With Niacin Did Not Cut Heart Risks : Shots - Health Blog : NPR A DNA methylation fingerprint of 1,628 human samples Unexpected?  UNC study: Pelvic widening continues throughout a person’s lifetime — A new study by Brian Wansink's group: 100 calorie Read more [...]

Forks vs feet obesity debate

On May 12 Drs. Yoni Freedhoff and Robert Ross held a debate on what should be the primary focus for obesity treatment: diet (Yoni) or exercise (Robert).  It seemed to me that the talks principally focused on what the primary cause of the obesity epidemic is by Yoni, and how exercise works in controlled environments and the benefits of exercise on co-morbidities by Ross.  Both of course recognize the importance of both for health and weight (especially maintenance as emphasized by Yoni), but that Read more [...]

Weekend Update

From last week: Yoni Freedhoff and Robert Ross debate what the primary focus for obesity treatment should be Forks vs. Feet: The Obesity Debate miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. [Proc Natl Acad Sci U S A. 2011] - PubMed result Another one, this time with vitamin E and alpha lipoic acid Antioxidant supplementation reduces mitochondria Biogenesis in rats The amount of omega 6 and omega 3 fatty acids may alter epigenetic programming Read more [...]

Weekend Update

Interesting links from last week: Skeletal Lipidomics: Regulation of Bone Metabolism by Fatty Acid Amide Family [Br J Pharmacol. 2011] - PubMed result   UV Modulation of Subcutaneous Fat Metabolism. [J Invest Dermatol. 2011] - PubMed result PPARα Is Regulated by miR-21 and miR-27b in Human Liver [Pharm Res. 2011] - PubMed result PLoS ONE: Plasma Proteome Profiles Associated with Inflammation, Angiogenesis, and Cancer Genome-wide association study identifies a single major Read more [...]

Generational increases in stochastic epigenetic variability to sustained methyl donor supplementation in mice

This recent paper in PLoS Genetics by Cheryl C. Y. Li and colleagues (from a group that did earlier work with the agouti mouse model) was really fascinating- they looked at changes in methylation variability in response to dietary supplementation of methyl donors across multiple generations of mice.  Some very novel and important findings (summary at the bottom). This time, they focused on CpG islands in the whole genome of (C57BL/6) mice fed methyl donors (similar to agouti studies: choline, betaine, Read more [...]

Weekend Update

From last week:   The NuVal system correlates with health outcomes: The association between a nutritional quality index and risk of chronic disease Fat maintenance is a predictor of the murine lifespan response to dietary restriction - Liao - 2011 - Aging Cell - Wiley Online Library "the function of reasoning is argumentative" The Reason We Reason | Wired Science | Wired.com Lasts over 1 week in rodents: Exercise protects the heart by producing nitric oxide, which is 'stored' Read more [...]

The Great Fat Debate

At the FNCE last November in Boston, there was a debate titled "The Great Fat Debate - Is There Validity in the Age Old Dietary Guidance?" The scientist participants were Walter Willett (Harvard), Dariush Mozaffarian (Harvard), Alice Lichtenstein (Tufts), and Lewis Kuller (Pittsburgh). If you weren't in attendance (like myself), thankfully the ADA put a video of the debate online here (~1h:15m). This month's issue of the JADA featured edited transcripts of each of the participants as well as a Read more [...]

Weekend Update

Some good reads last week:   Excellent post by Keith Grimaldi on folic acid and homocysteine and how existing research isn't delineating the differences between primary and secondary prevention when interpreting study results: Eurogene: If You Want to Practice Evidence Based Medicine then… Use the Evidence An interesting new paper by Michael Müller (@nutrigenomics): PLoS ONE: Dose-Dependent Effects of Dietary Fat on Development of Obesity in Relation to Intestinal Differential Gene Read more [...]