Weekend Update Leave a reply Some good reads last week: Excellent post by Keith Grimaldi on folic acid and homocysteine and how existing research isn’t delineating the differences between primary and secondary prevention when interpreting study results: Eurogene: If You Want to Practice Evidence Based Medicine then… Use the Evidence An interesting new paper by Michael Müller (@nutrigenomics): PLoS ONE: Dose-Dependent Effects of Dietary Fat on Development of Obesity in Relation to Intestinal Differential Gene Expression in C57BL/6J Mice An excellent series by Erik Davis about the differences between “nutritionists” and “dietitians” in Canada: The Legitimacy Diet, Part 1 – All Nutritionists are Certifiable « Canada « Skeptic North, The Legitimacy Diet, Part 2- Once More into the Fridge, & The Legitimacy Diet, Part 3- Science, It’s Alive Scott Gavura reviews the recent evidence: Do Calcium Supplements Cause Heart Attacks? « Science-Based Pharmacy Open access: The Australian Paradox: A Substantial Decline in Sugars Intake over the Same Timeframe that Overweight and Obesity Have Increased Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss–induced decrease in liver fat in humans Great post by Ed Yong on recent research: Individual neurons go to sleep while rats stay awake Another example (besides this) of a SNP on the 3’UTR (on UGT2B15) influencing (probably) microRNA binding & gene expression Differential allelic expression of c.1568C>A at UG… [Gene. 2011] – PubMed result PLoS ONE: Genetic Markers of Obesity Risk: Stronger Associations with Body Composition in Overweight Compared to Normal-Weight Children PLoS ONE: Predicting Diabetic Nephropathy Using a Multifactorial Genetic Model Biosphere 2 is still in action (an accidental calorie restriction experiment with Dr. Walford occurred there back in the early 90’s) Human terrarium, Biosphere 2, looking good at 20 – Yahoo! News Playing video games makes people eat more after compared to people just sitting and doing nothing and they do not compensate for it later by reducing food intake- adding more research showing that the increased food intake of sedentary, mentally engaging activities is probably more important than the lack of calorie burning during the activities: Is Screen Time More About “Calories In” Than “Calories Out”? | Dr. Sharma’s Obesity Notes Posted from Diigo. The rest of my favorite links are here.